Quality
Quality & Methodology
How Puralytix controls the quality of every analysis — from the reference material a sample is compared against, to the second-person review each report passes before it is released.
Controls
How we control quality
Every analytical run is bracketed by controls. If a control fails, the run is rejected and repeated — the result is never reported.
Reference standards
Identity and content are established against a reference material for the declared compound — pharmacopoeial or certified reference standards where they exist, and characterised in-house reference materials where they do not. The reference used is stated on the report.
System suitability
Before any sample is injected, the instrument must pass a system-suitability check: retention-time stability, peak shape, resolution and detector response all have to sit within defined limits for that method.
Calibration
Quantitative results (content, concentration, purity by area) are read from multi-point calibration curves prepared fresh for the run, not from a single reference injection.
Blanks and duplicates
Solvent blanks are run between samples to rule out carry-over, and a proportion of samples are prepared and analysed in duplicate to monitor repeatability.
Reporting limits
Anything below the method’s limit of quantification is reported as “below reporting limit”, never as zero. Where a value is close to a limit, the report says so.
Second-person review
No report leaves the laboratory on the analyst’s signature alone. The raw data, integration and calculations are reviewed by a second qualified person before the report is issued and its verification key is activated.
Methods
Techniques at a glance
Which technique is used depends on the compound class and the question being asked. Most analyses combine two.
| Technique | Used for | What it establishes | What it does not establish |
|---|---|---|---|
| HPLC-UV Reversed-phase, UV detection |
Purity and content of peptides, SARMs, SERMs and pharmaceutical compounds | Chromatographic purity (% area), content against a reference (mg per vial or per unit) | Identity on its own — a matching retention time is supporting, not conclusive, evidence |
| LC-MS Electrospray, accurate mass |
Identity confirmation of peptides and non-volatile small molecules | That the observed molecular mass matches the declared compound; detection of related substances | Biological activity, or the presence of contaminants it was not asked to look for |
| GC-MS Electron ionisation, library matching |
Anabolic esters, oral compounds, volatile carriers and solvent screening | Identity of volatile and semi-volatile components; screening of oil and solvent matrices for unexpected substances | Non-volatile or thermally unstable compounds such as peptides |
| Heavy-metal screen ICP-MS, where included |
Selected analyses on request | Whether lead, mercury, arsenic and cadmium are present above the stated reporting limit | Microbiological quality, endotoxin or sterility — these are not offered |
Handling
Sample handling and chain of custody
Every sample is booked in against its order reference on the day it arrives, photographed as received, and stored sealed under conditions appropriate to the sample type until analysis. The laboratory record for an order links the sample, the instrument data files and the issued report.
Remaining sample material is retained for 30 days after the report is issued so that a result can be queried or re-run, and is then destroyed. Samples that arrive without a valid order reference cannot be matched to an order and are held for 14 days before disposal.
Booked in
Same day as receipt
Sample retention
30 days after report
Raw data retention
Available as an add-on
Report review
Two-person release
Reports
What every report contains
Sample identification
Report ID, order reference, sample description as received, form and declared label claim.
Method statement
The technique, detection method and reference material used, so the result can be interpreted — and, if you wish, repeated elsewhere.
Results with limits
Each result alongside its reporting limit or acceptance criterion, and a clear overall outcome.
Verification block
The report ID, verification key and a QR code linking straight to the public verification page.
Dates and sign-off
Date of receipt, date of analysis and date of issue, with the release recorded in the laboratory record.
Scope statement
A plain statement of what the analysis does and does not show, so a result cannot be quoted beyond its meaning.
Limitations, stated plainly
An analytical report describes the sample we received, on the date we analysed it, using the method stated. It does not describe other units from the same batch, it does not test for anything it was not asked to test for, and it says nothing about whether a substance is safe, lawful or suitable for any use. If a result is ever withdrawn or corrected, the original report’s verification status changes to Revoked or Superseded — so the public verification page always reflects the current position.
Questions about a method?
If you need a specific technique, detection limit or reference standard for your work, ask before ordering and we will confirm whether it is available.